Emerging Therapeutic Strategies for Familial Hypertrophic Cardiomyopathy: From Beta-Blockers to Gene Therapy
Abstract
The treatment landscape for Familial Hypertrophic Cardiomyopathy (HCM) has evolved significantly, from traditional beta-blockers and calcium channel blockers to novel targeted therapies. This review highlights the latest advancements in pharmacologic, interventional, and genetic approaches to HCM management. We discuss myosin inhibitors, such as mavacamten and aficamten, and their impact on cardiac contractility. Additionally, we review septal reduction therapies, implantable cardioverter-defibrillators (ICDs), and the potential of RNA-based and CRISPR gene-editing therapies in disease modification. The integration of precision medicine in HCM treatment is poised to revolutionize patient outcomes.
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